Ro 61-8048 |CAS:199666-03-0 Probechem Biochemicals

Chemical Structure : Ro 61-8048

CAS No.: 199666-03-0

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Ro 61-8048 (Ro-61-8048)

货号: PC-42997Not For Human Use, Lab Use Only.

Ro 61-8048 is a potent, orally active Kynurenine 3-monooxygenase (KMO) inhibitor with IC50 of 37 nM.

规格	价格	库存
10 mg	￥750	In stock
25 mg	￥1450	In stock
100 mg	￥4250	In stock
250 mg	￥7250	In stock

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生物&药学活性

Ro 61-8048 is a potent, orally active Kynurenine 3-monooxygenase (KMO) inhibitor with IC50 of 37 nM; effectively blocks rat and gerbil kynurenine 3-hydroxylase after oral administration, with ED50 of 3-5 uM/kg range in gerbil brain, reduce ischemic brain damage in models of focal or global brain ischemia; also improves dystonia in a genetic model of paroxysmal dyskinesia.

物理化学性质&存储条件

分子量	421.4475
分子式	C17H15N3O6S2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	DMSO: ≥ 59 mg/mL
Chemical Name/SMILES	Benzenesulfonamide, 3,4-dimethoxy-N-[4-(3-nitrophenyl)-2-thiazolyl]-

参考文献

1. Röver S, et al. J Med Chem. 1997 Dec 19;40(26):4378-85.

2. Chiarugi A, et al. FEBS Lett. 1999 Jun 18;453(1-2):197-200.

3. Cozzi A, et al. J Cereb Blood Flow Metab. 1999 Jul;19(7):771-7.

4. Richter A, et al. Eur J Pharmacol. 2003 Sep 30;478(1):47-52.

Ro 61-8048 (Ro-61-8048)

生物&药学活性

物理化学性质&存储条件

参考文献

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Ro 61-8048 (Ro-61-8048)

生物&药学活性

物理化学性质&存储条件

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