Ro 60-0175 fumarate | 5-HT2C agonist | Probechem Biochemicals

Chemical Structure : Ro 60-0175 fumarate

CAS No.: 169675-09-6

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Ro 60-0175 fumarate (Ro 600175 fumarate)

货号: PC-35019Not For Human Use, Lab Use Only.

Ro 60-0175 fumarate is a potent, selective 5-HT2C receptor agonist with pKi of 9, 7.5, 5.4, 5.2 and 5.6 for human 5-HT2C, 2A, 1A, 6 and 7 receptors respectively.

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5 mg	￥2380	In stock
10 mg	￥3780	In stock
50 mg	￥3780	In stock
100 mg		Get quote

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生物&药学活性

Ro 60-0175 fumarate is a potent, selective 5-HT2C receptor agonist with pKi of 9, 7.5, 5.4, 5.2 and 5.6 for human 5-HT2C, 2A, 1A, 6 and 7 receptors respectively.
Ro 60-0175 induces hypolocomotion in rats at doses greater than 0.5 mg/kg s.c.
Ro 60-0175 (0.3 and 1 mg/kg s.c.) simultaneously reduces both unpunished and punished lever pressing, a profile consistent with sedation, induces sedative-like responses via 5-HT(2C) receptor activation in vivo.

物理化学性质&存储条件

分子量	342.751
分子式	C15H16ClFN2O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(S)-1-(6-chloro-5-fluoro-1H-indol-1-yl)propan-2-amine fumarate

参考文献

1. Damjanoska KJ, et al. J Pharmacol Exp Ther. 2003 Mar;304(3):1209-16.

2. Vickers SP, et al. Br J Pharmacol. 2000 Jul;130(6):1305-14.

3. Kennett G, et al. Eur J Pharmacol. 2000 Jan 10;387(2):197-204.

4. Jenck F, et al. Eur Neuropsychopharmacol. 1998 Aug;8(3):161-8.

Ro 60-0175 fumarate (Ro 600175 fumarate)

生物&药学活性

物理化学性质&存储条件

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Ro 60-0175 fumarate (Ro 600175 fumarate)

生物&药学活性

物理化学性质&存储条件

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