Ro 46-2005 | Endothelin receptor antagonist | Probechem Biochemicals

Chemical Structure : Ro 46-2005

CAS No.: 150725-87-4

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Ro 46-2005 (Ro46-2005, Ro 462005)

货号: PC-45639Not For Human Use, Lab Use Only.

Ro 46-2005 is the first synthetic orally active nonpeptide antagonist of endothelin receptor with equipotent potency (IC50=0.2-0.5 uM) for ETA and ETB.

规格	价格	库存
5 mg	￥780	In stock
10 mg	￥1280	In stock
25 mg	￥2280	In stock
50 mg	￥3780	In stock
100 mg		Get quote

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生物&药学活性

Ro 46-2005 is the first synthetic orally active nonpeptide antagonist of endothelin receptor with equipotent potency (IC50=0.2-0.5 uM) for ETA and ETB.
Ro 46-2005 has no effect on plasma concentrations of big ET-1 and only a minor effect on those of ET-3.
Ro 46-2005 is sufficient to inhibit the pressor effect of the precursor big ET-1 at much lower doses (1 to 10 mg/kg i.v.).

物理化学性质&存储条件

分子量	473.542
分子式	C23H27N3O6S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	DMSO: ≥ 28 mg/mL
Chemical Name/SMILES	Benzenesulfonamide, 4-(1,1-dimethylethyl)-N-[6-(2-hydroxyethoxy)-5-(3-methoxyphenoxy)-4-pyrimidinyl]-

参考文献

1. Clozel M, et al. Nature. 1993 Oct 21;365(6448):759-61.

2. Breu V, et al. FEBS Lett. 1993 Nov 15;334(2):210-4.

3. Clozel M, et al. J Cardiovasc Pharmacol. 1993;22 Suppl 8:S377-9.

Ro 46-2005 (Ro46-2005, Ro 462005)

生物&药学活性

物理化学性质&存储条件

参考文献

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Ro 46-2005 (Ro46-2005, Ro 462005)

生物&药学活性

物理化学性质&存储条件

参考文献

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