RO 27-3225 | MC4R agonist | Probechem Biochemicals

Chemical Structure : Ro 27-3225

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Ro 27-3225 (Ro27-3225, Ro 27-3225 trifluoroacetate salt)

货号: PC-36115Not For Human Use, Lab Use Only.

Ro 27-3225 (Ro27-3225, Ro 27-3225 trifluoroacetate salt) is a potent, selective melanocortin melanocortin receptor MC4R agonist with EC50 of 1 nM, >30-fold selectivity over MC3R.

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生物&药学活性

Ro 27-3225 (Ro27-3225, Ro 27-3225 trifluoroacetate salt) is a potent, selective melanocortin melanocortin receptor MC4R agonist with EC50 of 1 nM, >30-fold selectivity over MC3R.
Ro 27-3225 shows some activity at the MC1 receptor (EC50=8 nM), reverses hemorrhagic shock, reduces multiple organ damage, and improves survival.

物理化学性质&存储条件

分子量	784.91 (free base)
分子式	C41H53F3N12O8
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	Butir-His-D-Phe-Arg-Trp-Sar-NH2 trifluoracetate salt

参考文献

1. Spaccapelo L, et al. Eur J Pharmacol. 2011 Nov 30;670(2-3):479-86.

2. Minutoli L, et al. Crit Care Med. 2011 May;39(5):1089-96.

3. Benoit SC, et al. J Neurosci. 2000 May 1;20(9):3442-8.

4. Agosti F, et al. Eur J Neurosci. 2014 Sep;40(5):2755-65.

Ro 27-3225 (Ro27-3225, Ro 27-3225 trifluoroacetate salt)

生物&药学活性

物理化学性质&存储条件

参考文献

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Ro 27-3225 (Ro27-3225, Ro 27-3225 trifluoroacetate salt)

生物&药学活性

物理化学性质&存储条件

参考文献

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