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首页-小分子抑制剂&激动剂-Membrane Transporter/Ion Channel-iGluR-Ro 25-6981
Ro 25-6981

Chemical Structure : Ro 25-6981

CAS No.: 169274-78-6

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Ro 25-6981 (Ro25-6981)

货号: PC-22280Not For Human Use, Lab Use Only.

Ro 25-6981 is a potent and selective antagonist of NMDA receptors containing NR2B subunits with IC50 of 3 nM for inhibition 3H-MK-801 binding to rat forebrain membranes.

规格 价格 库存 数量
5 mg ￥980 In stock
10 mg ￥1480 In stock
25 mg ￥2580 In stock
50 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Ro 25-6981 is a potent and selective antagonist of NMDA receptors containing NR2B subunits with IC50 of 3 nM for inhibition 3H-MK-801 binding to rat forebrain membranes.
Ro 25-6981 blocks NMDA receptor subtypes expressed in Xenopus oocytes with the subunit combinations NR1C & NR2B with IC50 of 9 nM, >5000-fold selectivity over NR1C & NR2A.
Ro 25-6981 protected cultured cortical neurons against glutamate toxicity (16 h exposure to 300 microM glutamate) and combined oxygen and glucose deprivation (60 min followed by 20 h recovery) with IC50 values of 0.4 microM and 0.04 microM, respectively.
Ro 25-6981 induced antinociception without motor dysfunction in vivo.

物理化学性质&存储条件

分子量 339.48
分子式 C22H29NO2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

4-((1R,2S)-3-(4-benzylpiperidin-1-yl)-1-hydroxy-2-methylpropyl)phenol

参考文献

1. Pinard E, et al. Bioorg Med Chem Lett. 2001 Aug 20;11(16):2173-6.

2. Lynch DR, et al. Eur J Pharmacol. 2001 Mar 30;416(3):185-95.

3. Fischer G, et al. J Pharmacol Exp Ther. 1997 Dec;283(3):1285-92.

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