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首页-小分子抑制剂&激动剂-GPCR-Vasoactive intestinal peptide receptor (VIPR)-Ro 25-1553
Ro 25-1553

Chemical Structure : Ro 25-1553

CAS No.: 159427-08-4

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Ro 25-1553 (Ro25-1553)

货号: PC-20660Not For Human Use, Lab Use Only.

Ro 25-1553 is a potent, selective VIPR2 agonist and a cyclic peptide analog of vasoactive intestinal peptide (VIP), displaces the radioligand 125I-VIP from rat forebrain membranes with IC50 of 4.98 nM.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    Ro 25-1553 is a potent, selective VIPR2 agonist and a cyclic peptide analog of vasoactive intestinal peptide (VIP), displaces the radioligand 125I-VIP from rat forebrain membranes with IC50 of 4.98 nM.
    Ro 25-1553 is 24 to 89 times more potent than VIP as a relaxant of guinea pig trachea.
    Ro 25-1553 is inactive in a battery of 40 other binding assays (e.g., muscarinic, histamine, LTs, Ca++, TxA2, endothelin, alpha and beta adrenergic, platelet-activating factor, neurokinins, etc.) at 10 uM.
    Ro 25-1553 exhibited potent smooth muscle relaxant activity in vitro.
    Ro 25-1553 inhibited pulmonary responses evoked by histamine, leukotriene D4, platelet-activating factor and acetylcholine after in vivo intratracheal administration.

    物理化学性质&存储条件

    分子量 3562.05
    分子式 C160H258N46O46
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20°C 12 个月; 4°C 6 个月
    配置液
    -80°C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    L-Threoninamide, N-acetyl-L-histidyl-L-seryl-L-α-aspartyl-L-alanyl-L-valyl-L-phenylalanyl-L-threonyl-L-α-glutamyl-L-asparaginyl-L-tyrosyl-L-threonyl-L-lysyl-L-leucyl-L-arginyl-L-lysyl-L-glutaminyl-L-norleucyl-L-alanyl-L-alanyl-L-lysyl-L-lysyl-L-tyrosyl-L-leucyl-L-asparaginyl-L-α-aspartyl-L-leucyl-L-lysyl-L-lysylglycylglycyl-, (25→21)-lactam

    参考文献

    1. O'Donnell M, et al. J Pharmacol Exp Ther. 1994 Sep;270(3):1282-8.

    2. O'Donnell M, et al. J Pharmacol Exp Ther. 1994 Sep;270(3):1289-94.

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