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首页-小分子抑制剂&激动剂-Cell Cycle/DNA Damage-Cyclin-dependent Kinase (CDK)-Riviciclib
Riviciclib

Chemical Structure : Riviciclib

CAS No.: 920113-03-7

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Riviciclib (P276-00 hydrochloride)

货号: PC-61279Not For Human Use, Lab Use Only.

Riviciclib (P276-00 hydrochloride) is a potent CDK inhibitor with IC50 of 79 nM, 63 nM and 20 nM for Cdk4/cyclin D1, Cdk1/cyclin B and Cdk9/cyclin T1, respectively.

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5 mg ￥1480 In stock
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25 mg ￥3980 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Riviciclib (P276-00 hydrochloride) is a potent CDK inhibitor with IC50 of 79 nM, 63 nM and 20 nM for Cdk4/cyclin D1, Cdk1/cyclin B and Cdk9/cyclin T1, respectively.
Riviciclib (P276-00 hydrochloride) weakly inhibits Cdk2/cyclin A, Cdk2/cyclin E, Cdk6/cyclin D3 and Cdk7/cyclin H with IC50 of 0.2-3 uM.
Riviciclib (P276-00 hydrochloride) shows potent antiproliferative effects against various human cancer cell lines (IC50=200-800 nM).
Riviciclib (P276-00 hydrochloride) induces G1-G2 arrest, shows antitumor activity on cisplatin-resistant cells and significant in vivo efficacy in tumor models.

物理化学性质&存储条件

分子量 438.3
分子式 C21H20ClNO5.HCl
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

2-(2-chlorophenyl)-5,7-dihydroxy-8-((2R,3S)-2-(hydroxymethyl)-1-methylpyrrolidin-3-yl)-4H-chromen-4-one hydrochloride

参考文献

1. Joshi KS, et al. Mol Cancer Ther. 2007 Mar;6(3):918-25.

2. Joshi KS, et al. Mol Cancer Ther. 2007 Mar;6(3):926-34.

3. Raje N, et al. Leukemia. 2009 May;23(5):961-70.

4. Rathos MJ, et al. J Transl Med. 2012 Aug 8;10:161.

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