Rivaroxaban (BAY 59-7939) | FXa inhibitor | Probechem Biochemicals

Chemical Structure : Rivaroxaban

CAS No.: 366789-02-8

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Rivaroxaban (BAY 59-7939, BAY59-7939)

货号: PC-45897Not For Human Use, Lab Use Only.

Rivaroxaban (BAY 59-7939) is a highly potent and selective, direct FXa inhibitor with IC50 of 0.7 nM.

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10 mg	￥780	In stock
50 mg	￥1480	In stock
100 mg	￥2180	In stock
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生物&药学活性

Rivaroxaban (BAY 59-7939) is a highly potent and selective, direct FXa inhibitor with IC50 of 0.7 nM.
Rivaroxaban (BAY 59-7939) displays >10,000-fold greater selectivity than for other serine proteases, also inhibits prothrombinase activity (IC50=2.1 nM).
Rivaroxaban (BAY 59-7939) inhibits endogenous FXa more potently in human than rat plasma (IC50 21 nM vs 290 nM).
Rivaroxaban (BAY 59-7939) reduces venous thrombosis dose dependently (ED50=0.1 mg/kg i.v.) in a rat venous stasis model.
Rivaroxaban (BAY 59-7939) is orally active.

物理化学性质&存储条件

分子量	435.8813
分子式	C19H18ClN3O5S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-Thiophenecarboxamide, 5-chloro-N-[[(5S)-2-oxo-3-[4-(3-oxo-4-morpholinyl)phenyl]-5-oxazolidinyl]methyl]-

参考文献

1. Roehrig S, et al. J Med Chem. 2005 Sep 22;48(19):5900-8.

2. Perzborn E, et al. J Thromb Haemost. 2005 Mar;3(3):514-21.

3. Gerotziafas GT, et al. J Thromb Haemost. 2007 Apr;5(4):886-8.

Rivaroxaban (BAY 59-7939, BAY59-7939)

生物&药学活性

物理化学性质&存储条件

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Rivaroxaban (BAY 59-7939, BAY59-7939)

生物&药学活性

物理化学性质&存储条件

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