Rintodestrant (G1T48)

Chemical Structure : Rintodestrant

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货号: PC-38372Not For Human Use, Lab Use Only.

Rintodestrant (G1T48) is a potent, oral selective estrogen receptor degrader (SERD) with EC50 of 0.24 nM (ERα degradation, ICW), competitively binds to and degrades estrogen receptor (ER) and blocks ER signaling in ER-positive breast cancer cells.

规格	价格	库存	数量
25 mg		Get quote
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

Rintodestrant (G1T48) is a potent, oral selective estrogen receptor degrader (SERD) with EC50 of 0.24 nM (ERα degradation, ICW), competitively binds to and degrades estrogen receptor (ER) and blocks ER signaling in ER-positive breast cancer cells.

物理化学性质&存储条件

分子量	462.491
分子式	C26H19FO5S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(E)-3-(4-((2-(4-fluoro-2,6-dimethylbenzoyl)-6-hydroxybenzo[b]thiophen-3-yl)oxy)phenyl)acrylic acid

参考文献

1. Philippe Aftimos, et al. Cancer Res (2021) 81 (4_Supplement): PS12-04.

2. Kaitlyn J Andreano, et al. Breast Cancer Res Treat. 2020 Apr;180(3):635-646.

3. Xiong R, et al. J Med Chem. 2017;60(4):1325–1342.