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首页-小分子抑制剂&激动剂-Ras-Raf-MAPK-ERK Pathway-ERK-Rineterkib
Rineterkib

Chemical Structure : Rineterkib

CAS No.: 1715025-32-3

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Rineterkib (LTT462, LTT-462)

货号: PC-38371Not For Human Use, Lab Use Only.

Rineterkib (LTT462) is a small molecule inhibitor of ERK1/2, has demonstrated preclinical activity in multiple MAPK activated cancer cells and xenograft models.

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5 mg ￥1980 In stock
10 mg ￥2980 In stock
25 mg ￥4980 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Rineterkib (LTT462) is a small molecule inhibitor of ERK1/2, has demonstrated preclinical activity in multiple MAPK activated cancer cells and xenograft models.
Rineterkib (LTT462) significantly reduces the tumor volume in the Calu-6 human NSCLC subcutaneous tumor xenograft model in mice.

物理化学性质&存储条件

分子量 578.434
分子式 C26H27BrF3N5O2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

4-(3-amino-6-((1S,3S,4S)-3-fluoro-4-hydroxycyclohexyl)pyrazin-2-yl)-N-((S)-1-(3-bromo-5-fluorophenyl)-2-(methylamino)ethyl)-2-fluorobenzamide

参考文献

1. Asaf Maoz, et al. Expert Opin Emerg Drugs. 2019 Dec;24(4):239-253.

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