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首页-小分子抑制剂&激动剂-Antibiotics and Antivirals-Bacterial-Ridinilazole
Ridinilazole

Chemical Structure : Ridinilazole

CAS No.: 308362-25-6

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Ridinilazole (SMT19969)

货号: PC-22943Not For Human Use, Lab Use Only.

Ridinilazole (SMT19969) is a narrow-spectrum, non-absorbable antimicrobial against Clostridium difficile with MIC of 0.125 to 0.5 ug/ml, MIC90 of 0.25 ug/mL, including ribotype 027 strains.

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5 mg ￥1280 In stock
10 mg ￥1980 In stock
25 mg ￥3480 In stock
50 mg ￥5480 In stock
100 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Ridinilazole (SMT19969) is a narrow-spectrum, non-absorbable antimicrobial against Clostridium difficile with MIC of 0.125 to 0.5 ug/ml, MIC90 of 0.25 ug/mL, including ribotype 027 strains.
Ridinilazole (SMT19969) is more active against C. difficile isolates than fidaxomicin (range, 0.06 to 1 μg/ml; MIC90, 0.5 μg/ml) and two to six dilutions lower than either vancomycin or metronidazole.
Ridinilazole (SMT19969) is generally less active against Gram-negative anaerobes, especially the Bacteroides fragilis group species, than vancomycin and metronidazole. SMT19969 showed limited activity against other Gram-positive anaerobes, including Bifidobacteria species, Eggerthella lenta, Finegoldia magna, and Peptostreptococcus anaerobius, with MIC90s of >512, >512, 64, and 64 μg/ml, respectively.

物理化学性质&存储条件

分子量 388.43
分子式 C24H16N6
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

2,2'-Di(pyridin-4-yl)-1H,1'H-5,5'-bibenzo[d]imidazole

参考文献

1. Sattar A, et al. J Antimicrob Chemother. 2015;70(6):1757-62.

2. Corbett D, et al. J Antimicrob Chemother. 2015;70(6):1751-6.

3. Goldstein EJ, et al. Antimicrob Agents Chemother. 2013 Oct;57(10):4872-6.

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