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首页-小分子抑制剂&激动剂-Others-Other Targets-Rhoifolin
Rhoifolin

Chemical Structure : Rhoifolin

CAS No.: 17306-46-6

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Rhoifolin

货号: PC-27550Not For Human Use, Lab Use Only.

Rhoifolin is a natural flavonoid with anti-inflammatory and antiparasitic potential, is a a direct potassium channel modulatory factor 1 (KCMF1) binder that stabilizes AMPKα and ameliorates MASLD, also inhibits the specific binding site of ALDH2-PKCδ, significantly increases chemosensitivity.

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50 mg ￥1180 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Rhoifolin is a natural flavonoid with anti-inflammatory and antiparasitic potential, is a a direct potassium channel modulatory factor 1 (KCMF1) binder that stabilizes AMPKα and ameliorates MASLD, also inhibits the specific binding site of ALDH2-PKCδ, significantly increases chemosensitivity.
Rhoifolin selectively potentiates ILC3s effector function without affecting their proliferation, apoptosis, intestinal homing, developmental differentiation, or the distribution of CCR6+, NKp46+, and double-negative ILC3s subsets, directly targets NMNAT1.
Rhoifolin inhibits ferroptosis and alleviates pulmonary arterial hypertension via the TNF-alpha/TNF-R1/CASP8/CASP3 pathway.
Rhoifolin targets leukemia stem cells (LSCs) within the bone marrow microenvironment, work synergistically with conventional chemotherapy drugs, and exhibit no toxicity toward normal cells.

物理化学性质&存储条件

分子量 578.52
分子式 C27H30O14
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

7-(((2S,3R,4S,5S,6R)-4,5-Dihydroxy-6-(hydroxymethyl)-3-(((2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)tetrahydro-2H-pyran-2-yl)oxy)-5-hydroxy-2-(4-hydroxyphenyl)-4H-chromen-4-one

参考文献

1. Kenzerki RE, et al. Sci Rep. 2026 Jun 6. doi: 10.1038/s41598-026-56709-w.

2. Yang H, et al. Adv Sci (Weinh). 2026 Aug 7:e76935.

3. Tang M, et al. Metabolism. 2026 Sep;182:156651.

4. Deng S, et al. Phytomedicine. 2026 Jun;155:158095.

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