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首页-小分子抑制剂&激动剂-Cell Cycle/DNA Damage-Aurora Kinase-Reversine
Reversine

Chemical Structure : Reversine

CAS No.: 656820-32-5

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Reversine

货号: PC-21560Not For Human Use, Lab Use Only.

Reversine is a potent, ATP-competitive Aurora kinases inhibitor with IC50 of 400, 500 and 400 nM for Aurora A, Aurora B and Aurora C, respectively.

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25 mg ￥1580 In stock
50 mg ￥2480 In stock
100 mg ￥3980 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Reversine is a potent, ATP-competitive Aurora kinases inhibitor with IC50 of 400, 500 and 400 nM for Aurora A, Aurora B and Aurora C, respectively.
Reversine promotes the dedifferentiation of committed cells into multipotent progenitor-type cells.
Reversine inhibited colony formation of leukemic cells from patients with acute myeloid leukemia.

物理化学性质&存储条件

分子量 393.50
分子式 C21H27N7O
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

N6-Cyclohexyl-N2-(4-morpholinophenyl)-9H-purine-2,6-diamine

参考文献

1. D'Alise AM, et al. Mol Cancer Ther2008 May;7(5):1140-9.

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