Retinylamine | Visual cycle inhibitor | Probechem Biochemicals

Chemical Structure : Retinylamine

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Retinylamine (Ret-NH2)

货号: PC-28607Not For Human Use, Lab Use Only.

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100 mg		Get quote

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生物&药学活性

Retinylamine (Ret-NH2) is a potent inhibitor of the rod visual cycle, inhibits 11-cis-retinol production in isomerase assay with IC50 of 500 nM, potently and selectively inhibits the isomerization step of the retinoid cycle in vitro and in vivo.
Retinylamine (Ret-NH2) binds a protein(s) in the RPE microsomes, but it does not bind RPE65, a protein implicated in the isomerization reaction.
Retinylamine (Ret-NH2) inhibits the regeneration of visual chromophore in rods and, in turn, severely attenuates rod responses, it has a much smaller effect on cone function in mice.
Retinylamine (Ret-NH2) inhibits regeneration of vision chromophore in vivo.

物理化学性质&存储条件

分子量	285.48
分子式	C20H31N
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(2E,4E,6E,8E)-3,7-dimethyl-9-(2,6,6-trimethylcyclohex-1-en-1-yl)nona-2,4,6,8-tetraen-1-amine

参考文献

1. Wolber PK, et al. Proc Natl Acad Sci U S A. 1984 Apr;81(8):2303-7.

Retinylamine (Ret-NH2)

生物&药学活性

物理化学性质&存储条件

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Retinylamine (Ret-NH2)

生物&药学活性

物理化学性质&存储条件

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