Retaspimycin hydrochloride |CAS:857402-63-2 Probechem Biochemicals

Chemical Structure : Retaspimycin hydrochloride

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Retaspimycin hydrochloride (IPI-504;IPI504;IPI 504)

货号: PC-42456Not For Human Use, Lab Use Only.

A water-soluble derivative of 17-AAG and HSP90 inhibitor.

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生物&药学活性

Retaspimycin hydrochloride (IPI-504) is a water-soluble derivative of 17-AAG and HSP90 inhibitor.
Retaspimycin hydrochloride (IPI-504) induces KIT degradation, tumor shrinkage, and cell proliferation arrest in xenograft models of gastrointestinal stromal tumors.

物理化学性质&存储条件

分子量	624.1652
分子式	C31H46ClN3O8
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	DMSO: ≥ 56 mg/mL
Chemical Name/SMILES	Geldanamycin, 18,21-didehydro-17-demethoxy-18,21-dideoxo-18,21-dihydroxy-17-(2-propen-1-ylamino)-, hydrochloride (1:1)

参考文献

1. Floris G, et al. Mol Cancer Ther. 2011 Oct;10(10):1897-908.

2. Hanson BE, et al. Expert Opin Investig Drugs. 2009 Sep;18(9):1375-83.

3. Oh WK, et al. Urology. 2011 Sep;78(3):626-30.

4. Siegel D, et al. Leuk Lymphoma. 2011 Dec;52(12):2308-15.

Retaspimycin hydrochloride (IPI-504;IPI504;IPI 504)

生物&药学活性

物理化学性质&存储条件

参考文献

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Retaspimycin hydrochloride (IPI-504;IPI504;IPI 504)

生物&药学活性

物理化学性质&存储条件

参考文献

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