Reproxalap | RASP inhibitor | Probechem Biochemicals

Chemical Structure : Reproxalap

CAS No.: 916056-79-6

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Reproxalap (ADX-102, ADX102)

货号: PC-72005Not For Human Use, Lab Use Only.

Reproxalap (ADX-102) is a novel inhibitor of reactive aldehyde species (RASP) for the treatment of ocular inflammation.

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50 mg	￥1580	In stock
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生物&药学活性

Reproxalap (ADX-102) is a novel inhibitor of reactive aldehyde species (RASP) for the treatment of ocular inflammation.
Reproxalap (ADX-102) protected octadecanal (C18:0-al) induced cytotoxicity and apoptosis in cellular model for SLS (Sjögren-Larsson syndrome), also inhibited etabolism of C18:0-al to fatty alcohol (octadecanol).
Reproxalap (ADX-102) is a novel small-molecule RASP inhibitor in development to treat NAU, allergic conjunctivitis, and dry eye disease.
Results from nonclinical studies indicate that reproxalap and related molecules have the potential to mitigate ocular inflammation related to NAU and other inflammatory eye conditions, such as postsurgical inflammation and diabetic retinopathy.

物理化学性质&存储条件

分子量	236.699
分子式	C12H13ClN2O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-(3-Amino-6-chloroquinolin-2-yl)propan-2-ol

参考文献

1. Mandell KJ, et al. J Ocul Pharmacol Ther. 2020 Dec;36(10):732-739.

Reproxalap (ADX-102, ADX102)

生物&药学活性

物理化学性质&存储条件

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Reproxalap (ADX-102, ADX102)

生物&药学活性

物理化学性质&存储条件

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