Reparixin L-lysine salt

Chemical Structure : Reparixin L-lysine salt

CAS No.: 266359-93-7

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货号: PC-23972Not For Human Use, Lab Use Only.

Reparixin L-lysine salt (Repertaxin) is a potent, selective, non-competitive allosteric inhibitor of CXCL8 receptor CXCR1 and CXCR2 activation with IC50 of 1 nM and 100 nM, respectively.

规格	价格	库存
5 mg	￥1280	In stock
10 mg	￥1980	In stock
25 mg	￥3480	In stock
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

Reparixin L-lysine salt (Repertaxin) is a potent, selective, non-competitive allosteric inhibitor of CXCL8 receptor CXCR1 and CXCR2 activation with IC50 of 1 nM and 100 nM, respectively.
Reparixin inhibited the chemotaxis of neutrophils induced by human CXCL8 or rat CINC-1, but not that induced by fMLP, PAF or LTB(4), in a concentration-dependent manner.
Reparixin also prevented CXCL8-induced calcium influx but not CXCL8 binding to purified rat neutrophils.
Reparixin dose-dependently (3-30 mg kg(-1)) inhibited the increase in vascular permeability and neutrophil influx.
Reparixin effectively suppressed the increase in tissue (intestine and lungs) and serum concentrations of TNF-alpha and the reperfusion-associated lethality.

物理化学性质&存储条件

分子量	428.57
分子式	C20H34N3O5S-
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(R)-2-(4-Isobutylphenyl)-N-(methylsulfonyl)propanamide L-lysine salt

参考文献

1. Moriconi A, et al. J Med Chem. 2007 Aug 23;50(17):3984-4002.

2. Garau A, et al. Eur Cytokine Netw. 2006 Mar;17(1):35-41.

3. Bertini R, et al. Proc Natl Acad Sci U S A. 2004 Aug 10;101(32):11791-6.