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首页-小分子抑制剂&激动剂-Epigenetics-Histone Acetyltransferase (HAT)-Remodelin
Remodelin

Chemical Structure : Remodelin

CAS No.: 949912-58-7

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Remodelin (NAT10 inhibitor)

货号: PC-45051Not For Human Use, Lab Use Only.

Remodelin is a potent inhibitor of the acetyl-transferase protein NAT10 that acetylates both histones and microtubules.

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10 mg ￥880 In stock
25 mg ￥1380 In stock
50 mg ￥2180 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Remodelin is a potent inhibitor of the acetyl-transferase protein NAT10 that acetylates both histones and microtubules.
Remodelin significantly reduces the prevalence of misshapen nuclei in HGPS cells, prevents FTI-induced nuclear shape defects in normal fibroblasts and U2OS cells.
Remodelin does not affect Golgi apparatus integrity or tubulin polymer assembly, and does not cause cells to accumulate in mitosis.

物理化学性质&存储条件

分子量 282.3635
分子式 C15H14N4S
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

Benzonitrile, 4-[2-(2-cyclopentylidenehydrazinyl)-4-thiazolyl]-

参考文献

1. Larrieu D, et al. Science. 2014 May 2;344(6183):527-32.

2. Mathieu J, et al. Cell Stem Cell. 2016 Jul 7;19(1):3-4.

3. Cobb AM, et al. Aging Cell. 2016 Jul 27. doi: 10.1111/acel.12506.

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