Regorafenib monohydrate |CAS:1019206-88-2 Probechem Biochemicals

Chemical Structure : Regorafenib monohydrate

CAS No.: 1019206-88-2

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Regorafenib monohydrate (BAY 73-4506 monohydrate)

货号: PC-42531Not For Human Use, Lab Use Only.

A potent multikinase inhibitor that potently inhibits these endothelial cell kinases in biochemical and cellular kinase phosphorylation assays with nanomolar range (IC50=3-200 nM).

规格	价格	库存
50 mg	￥760	In stock
100 mg	￥1160	In stock
200 mg	￥2080	In stock

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生物&药学活性

A potent multikinase inhibitor that potently inhibits these endothelial cell kinases in biochemical and cellular kinase phosphorylation assays with nanomolar range (IC50=3-200 nM); inhibits VEGFR1/2/3, PDGFRβ, FGFR1, KIT, RET and B-RAF etc.; exhibits potent dose-dependent TGI in various preclinical human xenograft models in mice; orally active.

Colon Cancer

Approved

物理化学性质&存储条件

分子量	500.8307
分子式	C21H17ClF4N4O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-Pyridinecarboxamide, 4-[4-[[[[4-chloro-3-(trifluoromethyl)phenyl]amino]carbonyl]amino]-3-fluorophenoxy]-N-methyl-, hydrate (1:1)

参考文献

1. Wilhelm SM, et al. Int J Cancer. 2011 Jul 1;129(1):245-55.

2. Mross K, et al. Clin Cancer Res. 2012 May 1;18(9):2658-67.

3. Abou-Elkacem L, et al. Mol Cancer Ther. 2013 Jul;12(7):1322-31.

Regorafenib monohydrate (BAY 73-4506 monohydrate)

生物&药学活性

物理化学性质&存储条件

参考文献

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Regorafenib monohydrate (BAY 73-4506 monohydrate)

生物&药学活性

物理化学性质&存储条件

参考文献

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