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首页-新冠病毒相关-SARS-CoV-2 Antibodies-Regdanvimab
Regdanvimab

Chemical Structure : Regdanvimab

CAS No.: 2444308-95-4

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Regdanvimab (CT-P59)

货号: PC-38893Not For Human Use, Lab Use Only.

Regdanvimab (Regkirona, CT-P59) is a recombinant human immunoglobulin G1 antibody targeted against SARS-CoV-2 sipke RBD, shows therapeutic effect against SARS-CoV-2 South African variants.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    Regdanvimab (Regkirona, CT-P59) is a recombinant human immunoglobulin G1 antibody targeted against SARS-CoV-2 sipke RBD, shows therapeutic effect against SARS-CoV-2 South African variants.
    CT-P59 neutralized B.1.1.7 variant to a similar extent as to wild type virus.
    CT-P59 showed reduced binding affinity against a RBD (receptor binding domain) triple mutant containing mutations defining B.1.351 (K417N/E484K/N501Y), also showed reduced potency against the SA variant in live virus and pseudovirus neutralization assay systems.
    CT-P59 decrease B.1.351 viral load in the upper and lower respiratory tracts, comparable to that observed for the wild type virus.

    Isotype: IgG1-lambda.
    Anti-[human severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike (S) protein, receptor binding domain (RBD)], humanized and Homo sapiens monoclonal antibody.

    物理化学性质&存储条件

    分子量
    分子式
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20°C 12 个月; 4°C 6 个月
    配置液
    -80°C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    参考文献

    1. Ryu DK, et al. Biochem Biophys Res Commun. 2021 Aug 20;566:135-140.

    2. Ryu DK, et al. Biochem Biophys Res Commun. 2021 Nov 12;578:91-96.

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