Regacin

Chemical Structure : Regacin

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货号: PC-20322Not For Human Use, Lab Use Only.

Regacin is a potent, specific inhibitor of bacterial AraC-like virulence regulator RegA with IC50 of 1.7 uM.

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25 mg		Get quote
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

Regacin is a potent, specific inhibitor of bacterial AraC-like virulence regulator RegA with IC50 of 1.7 uM.
Regacin does not inhibit the growth of C. rodentium and is not cytotoxic to mammalian cells.
Regacin (100 uM) inhibits the synthesis and secretion of virulence proteins in C. rodentium.
Regacin interferes with the binding of RegA to its DNA target.
Regacin (50 mg/kg, oral) suppresses C. rodentium virulence, and reduces intestinal colonization.
Regacin significantly inhibits the ability of RegA-related virulence regulatory proteins Rns and RegR to activate the transcription of their target promoters, but has little or no effect on the activity of AggR and ToxT.

物理化学性质&存储条件

分子量	257.75
分子式	C9H8ClN3S2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	5-[(4-chlorobenzyl)thio]-1,3,4-thiadiazol-2-amine

参考文献

1. Yang J, et al. J Biol Chem. 2013 Oct 25;288(43):31115-26.

Regacin

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物理化学性质&存储条件

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Regacin

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