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首页-小分子抑制剂&激动剂-Metabolic Enzyme/Protease-Matrix Metalloproteinase (MMP)-Rebimastat
Rebimastat

Chemical Structure : Rebimastat

CAS No.: 259188-38-0

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Rebimastat (BMS-275291, D2163)

货号: PC-72039Not For Human Use, Lab Use Only.

Rebimastat (BMS-275291, D2163) is a potent, broad spectrum matrix metalloproteinase (MMPs) inhibitor with potential antineoplastic activity, shows nM potency against MMP-1/2/7/9/14.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    Rebimastat (BMS-275291, D2163) is a potent, broad spectrum matrix metalloproteinases (MMPs) inhibitor with potential antineoplastic activity, shows nM potency against MMP-1/2/7/9/14.
    BMS-275291 inhibits tumor growth in a B16BL6 model of experimental metastasis, BMS-275291 treatment results in a dose-dependent reduction in the number of lung metastases.
    BMS-275291 also inhibits angiogenesis in a murine angiogenesis model with a dose-dependent inhibition of endothelial cell migration.
    Rebimastat (BMS-275291) induces extracellular matrix degradation, and inhibiting angiogenesis, tumor growth and invasion, and metastasis.

    物理化学性质&存储条件

    分子量 499.7
    分子式 C23H41N5O5S
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20°C 12 个月; 4°C 6 个月
    配置液
    -80°C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    (2S)-3,3-dimethyl-2-methylamino-N-[(2S)-4-methyl-2-[[(2S)-2-sulfanyl-4 -(3,4,4-trimethyl-2,5-dioxo-imidazolidin-1-yl)butanoyl]amino]pentanoyl ]butanamide

    参考文献

    1. Daniel P Becker, et al. J Med Chem. 2010 Sep 23;53(18):6653-80.

    2. Naglich JG, et al. Cancer Res. 2001 Dec 1;61(23):8480-5.

    3. Lockhart AC, et al. Clin Cancer Res. 2003 Feb;9(2):586-93.

    4. Rizvi NA, et al. Clin Cancer Res. 2004 Mar 15;10(6):1963-70.

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