Razaxaban |CAS:218298-21-6 Probechem Biochemicals

Chemical Structure : Razaxaban

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Razaxaban (DPC 906;DPC906;BMS-561389;BMS561389)

货号: PC-60955Not For Human Use, Lab Use Only.

Razaxaban (DPC906, BMS561389) is a highly potent, selective, and orally bioavailable factor Xa (FXa) inhibitor with Ki of o.19 nM, >5,000-fold selectivity over a series of related serine proteases.

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生物&药学活性

Razaxaban (DPC906, BMS561389) is a highly potent, selective, and orally bioavailable factor Xa (FXa) inhibitor with Ki of o.19 nM, >5,000-fold selectivity over a series of related serine proteases.
Razaxaban (DPC906, BMS561389) inhibits thrombus formation in a dose-dependent manner with an ID50 of 1.6 µmol kg-1 h-1 in rabbit arterio-venous shunt thrombosis model.

物理化学性质&存储条件

分子量	528.472
分子式	C24H20F4N8O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-(3-amino-1,2-benzoxazol-5-yl)-N-[4-[2-[(dimethylamino)methyl]imidazol-1-yl]-2-fluorophenyl]-5-(trifluoromethyl)pyrazole-3-carboxamide

参考文献

1. Quan ML, et al. J Med Chem. 2005 Mar 24;48(6):1729-44.

2. Wong PC, et al. J Thromb Thrombolysis. 2007 Aug;24(1):43-51.

3. Zhang D, et al. Drug Metab Dispos. 2008 Feb;36(2):303-15.

Razaxaban (DPC 906;DPC906;BMS-561389;BMS561389)

生物&药学活性

物理化学性质&存储条件

参考文献

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Razaxaban (DPC 906;DPC906;BMS-561389;BMS561389)

生物&药学活性

物理化学性质&存储条件

参考文献

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