Chemical Structure : Raltegravir potassium salt
CAS No.:
871038-72-1
Raltegravir potassium salt
(MK0518 potassium salt;MK-0518 potassium salt;MK 0518 potassium salt)
货号 : PC-42549Not For Human Use, Lab Use Only.
A potent, selective, orally bioavailable HIV-integrase inhibitor with IC50 of 15 nM.
规格 价格 库存 数量 10 mg ￥960 In stock 0 1 2 3 4 5 50 mg ￥3120 In stock 0 1 2 3 4 5 100 mg ￥4800 In stock 0 1 2 3 4 5
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纯度 & COA & 质检文件 纯度:
>98% (HPLC) Select Batch: PC-4254901
生物&药学活性
A potent, selective, orally bioavailable HIV-integrase inhibitor with IC50 of 15 nM; essentially inactive (IC50s>50 uM) against HCV Pol, HIV RT, HIV RNase-H, and human α/β/γ Pol; shows inhibitory activity against the wild type virus and a selection of mutants; the first HIV-integrase inhibitor for the treatment of HIV-1 infection.
HIV Infection
Approved
物理化学性质&存储条件
分子量
482.5067
分子式
C20H20FKN6O5
外观性状
Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility
10 mM in DMSO
Chemical Name/SMILES
4-Pyrimidinecarboxamide, N-[(4-fluorophenyl)methyl]-1,6-dihydro-5-hydroxy-1-methyl-2-[1-methyl-1-[[(5-methyl-1,3,4-oxadiazol-2-yl)carbonyl]amino]ethyl]-6-oxo-, potassium salt(1:1)
参考文献
1. Summa V, et al. J Med Chem. 2008 Sep 25;51(18):5843-55.
2. Malet I, et al. Antimicrob Agents Chemother. 2008 Apr;52(4):1351-8.
3. Cooper DA, et al. N Engl J Med. 2008 Jul 24;359(4):355-65.
