Raltegravir |CAS:518048-05-0 Probechem Biochemicals

Chemical Structure : Raltegravir

CAS No.: 518048-05-0

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Raltegravir (MK-0518;MK 0518;MK0518)

货号: PC-42548Not For Human Use, Lab Use Only.

Raltegravir (MK-0518) is a potent, selective, orally bioavailable HIV-integrase inhibitor with IC50 of 15 nM.

规格	价格	库存
5 mg (Free Sample)	￥280	In stock
10 mg	￥980	In stock
50 mg	￥1980	In stock
100 mg	￥3280	In stock
250 mg		Get quote
1 g		Get quote

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生物&药学活性

Raltegravir (MK-0518) is a potent, selective, orally bioavailable HIV-integrase inhibitor with IC50 of 15 nM.
Raltegravir (MK-0518) essentially inactive (IC50s>50 uM) against HCV Pol, HIV RT, HIV RNase-H, and human α/β/γ Pol.
Raltegravir (MK-0518) shows inhibitory activity against the wild type virus and a selection of mutants.
Raltegravir (MK-0518) is the first HIV-integrase inhibitor for the treatment of HIV-1 infection.

物理化学性质&存储条件

分子量	444.4164
分子式	C20H21FN6O5
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-Pyrimidinecarboxamide, N-[(4-fluorophenyl)methyl]-1,6-dihydro-5-hydroxy-1-methyl-2-[1-methyl-1-[[(5-methyl-1,3,4-oxadiazol-2-yl)carbonyl]amino]ethyl]-6-oxo-

参考文献

1. Summa V, et al. J Med Chem. 2008 Sep 25;51(18):5843-55.

2. Malet I, et al. Antimicrob Agents Chemother. 2008 Apr;52(4):1351-8.

3. Cooper DA, et al. N Engl J Med. 2008 Jul 24;359(4):355-65.

Raltegravir (MK-0518;MK 0518;MK0518)

生物&药学活性

物理化学性质&存储条件

参考文献

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Raltegravir (MK-0518;MK 0518;MK0518)

生物&药学活性

物理化学性质&存储条件

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