Ral inhibitor 1 |CAS:2249469-44-9 Probechem Biochemicals

Chemical Structure : Ral inhibitor 1

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Ral inhibitor 1

货号: PC-38330Not For Human Use, Lab Use Only.

Ral inhibitor 1 is a covalent inhibitor of RalB (Ras-like GTPase) activation, inhibits guanine exchange factor Rgl2-mediated nucleotide exchange of Ral GTPase, selectively inhibits Ral over Ras.

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生物&药学活性

Ral inhibitor 1 is a covalent inhibitor of RalB (Ras-like GTPase) activation, inhibits guanine exchange factor Rgl2-mediated nucleotide exchange of Ral GTPase, selectively inhibits Ral over Ras.
Ral inhibitor 1 inhibits RalB/Rgl2 interaction through covalent reaction at Tyr-82 with IC50 of 49.5 uM.
Ral (Ras-like) GTPases are directly activated by oncogenic Ras GTPases.

物理化学性质&存储条件

分子量	346.347
分子式	C12H11FN2O5S2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 1 Month
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Solubility	10 mM in DMSO
Chemical Name/SMILES	4-(N-(5-methoxypyridin-3-yl)sulfamoyl)benzenesulfonyl fluoride

参考文献

1. Khuchtumur Bum-Erdene, et al. Proc Natl Acad Sci U S A. 2020 Mar 31;117(13):7131-7139.

Ral inhibitor 1

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Ral inhibitor 1

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