Radotinib |CAS:926037-48-1 Probechem Biochemicals

Chemical Structure : Radotinib

CAS No.: 926037-48-1

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Radotinib (IY5511, IY-5511)

货号: PC-38025Not For Human Use, Lab Use Only.

Radotinib (IY-5511) is a potent and selective BCR-ABL1 tyrosine kinase inhibitor with IC50 of 34 nM for wild-type BCR-ABL1 kinase.

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10 mg	￥580	In stock
25 mg	￥980	In stock
100 mg	￥2480	In stock
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生物&药学活性

Radotinib (IY-5511) is a potent and selective BCR-ABL1 tyrosine kinase inhibitor with IC50 of 34 nM for wild-type BCR-ABL1 kinase.
Radotinib (IY-5511) displays high selectivity over c-kit (1,324 nM), PDGFR (PDGFRα, 75.5 nM; PDGFRβ, 130 nM) and src (>2,000 nM).
Radotinib (IY-5511) effectively inhibited the proliferation of common mutant clones of BCR-ABL1, with the exception of T315I.

物理化学性质&存储条件

分子量	530.5
分子式	C27H21F3N8O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-methyl-N-(3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl)-3-((4-(pyrazin-2-yl)pyrimidin-2-yl)amino)benzamide

参考文献

1. Kim SH, et al. Haematologica. 2014 Jul;99(7):1191-6.

2. Heo SK, et al. PLoS One. 2015 Jun 12;10(6):e0129853.

3. Kwak JY, et al. Clin Cancer Res. 2017 Dec 1;23(23):7180-7188.

4. Heo SK, et al. Sci Rep. 2017 Nov 10;7(1):15278.

Radotinib (IY5511, IY-5511)

生物&药学活性

物理化学性质&存储条件

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Radotinib (IY5511, IY-5511)

生物&药学活性

物理化学性质&存储条件

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