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首页-小分子抑制剂&激动剂-Membrane Transporter/Ion Channel-iGluR-Radiprodil
Radiprodil

Chemical Structure : Radiprodil

CAS No.: 496054-87-6

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Radiprodil (RGH-896, RGH896)

货号: PC-25808Not For Human Use, Lab Use Only.

Radiprodil (RGH-896) is a selective, negative allosteric modulator / antagonist of GluN2B-containing NMDA receptors (GluN2B) with IC50 of 3-10 nM, with no activity against NR2A receptors.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Radiprodil (RGH-896) is a selective, negative allosteric modulator / antagonist of GluN2B-containing NMDA receptors (GluN2B) with IC50 of 3-10 nM, with no activity against NR2A receptors.

物理化学性质&存储条件

分子量 397.41
分子式 C21H20FN3O4
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

2-(4-(4-Fluorobenzyl)piperidin-1-yl)-2-oxo-N-(2-oxo-2,3-dihydrobenzo[d]oxazol-6-yl)acetamide

参考文献

1. Bertocchi I, et al. Br J Pharmacol. 2024 Jun;181(12):1886-1894.

2. Michel A, et al. PLoS One. 2015 Aug 31;10(8):e0135949.

3. Rammes G, et al. Neuropharmacology. 2018 Sep 15;140:184-192.

4. Romain Labas, et al. Eur J Med Chem. 2011 Jun;46(6):2295-309.

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