Radalbuvir |CAS:1314795-11-3 Probechem Biochemicals

Chemical Structure : Radalbuvir

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Radalbuvir (GS 9669)

货号: PC-63008Not For Human Use, Lab Use Only.

Radalbuvir (GS-9669) is a highly optimized thumb site II nonnucleoside inhibitor of HCV NS5B polymerase with binding affinity of 1.35 nM for genotype 1b.

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生物&药学活性

Radalbuvir (GS-9669) is a highly optimized thumb site II nonnucleoside inhibitor of HCV NS5B polymerase with binding affinity of 1.35 nM for genotype 1b.
Radalbuvir (GS-9669) shows inhibition of WT genotype 1b replicon and NS5B M423T mutant replicon with EC50 of 6 nM and 12 nM respectively.

物理化学性质&存储条件

分子量	543.719
分子式	C30H41NO6S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-Thiophenecarboxylic acid, 5-(3,3-dimethyl-1-butyn-1-yl)-3-((cis-4-hydroxy-4-((((3S)-tetrahydro-3-furanyl)oxy)methyl)cyclohexyl)(((1R)-4-methyl-3-cyclohexen-1-yl)carbonyl)amino)-

参考文献

1. Lazerwith SE, et al. J Med Chem. 2014 Mar 13;57(5):1893-901.

2. Fenaux M, et al. Antimicrob Agents Chemother. 2013 Feb;57(2):804-10.

3. Dvory-Sobol H, et al. Antimicrob Agents Chemother. 2014 Nov;58(11):6599-606.

Radalbuvir (GS 9669)

生物&药学活性

物理化学性质&存储条件

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Radalbuvir (GS 9669)

生物&药学活性

物理化学性质&存储条件

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