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首页-小分子抑制剂&激动剂-Membrane Transporter/Ion Channel-Proton Pump-Rabeprazole
Rabeprazole

Chemical Structure : Rabeprazole

CAS No.: 117976-89-3

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Rabeprazole (LY307640)

货号: PC-24038Not For Human Use, Lab Use Only.

Rabeprazole (LY307640) is a second-generation proton pump inhibitor that irreversibly inactivates gastric H+/K+-ATPase, also is an uridine nucleoside ribohydrolase (UNH) inhibitor with IC50 of 0.3 uM.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Rabeprazole (LY307640) is a second-generation proton pump inhibitor that irreversibly inactivates gastric H+/K+-ATPase, also is an uridine nucleoside ribohydrolase (UNH) inhibitor with IC50 of 0.3 uM.
Rabeprazole inhibits the phosphorylation of ERK1/2 in the MKN-28 cells.
Rabeprazole attenuates the cell viability of the human gastric cancer cells.

物理化学性质&存储条件

分子量 359.44
分子式 C18H21N3O3S
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

2-(((4-(3-Methoxypropoxy)-3-methylpyridin-2-yl)methyl)sulfinyl)-1H-benzo[d]imidazole

参考文献

1. Tara A Shea, et al. Bioorg Med Chem Lett. 2014 Feb 15;24(4):1080-4.

2. Mengli Gu, et al. Oncol Lett. 2014 Oct;8(4):1739-1744.

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