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首页-小分子抑制剂&激动剂-Epigenetics-Histone Methyltransferase (HMTase)-Rabdosiin
Rabdosiin

Chemical Structure : Rabdosiin

CAS No.: 263397-69-9

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Rabdosiin ((+)-Rabdosiin)

货号: PC-23666Not For Human Use, Lab Use Only.

Rabdosiin is a tetramer of caffeic acid isolated from the stem of Ocimum sanctum, shows anti-allergic activity, anti-HIV activity and inhibition on DNA topoisomerase, also is a potential METTL8 inhibitor.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Rabdosiin is a tetramer of caffeic acid isolated from the stem of Ocimum sanctum, shows anti-allergic activity, anti-HIV activity and inhibition on DNA topoisomerase, also is a potential METTL8 inhibitor.
Rabdosiin exhibits hyaluronidase-inhibitory activity and scavenging activities against active oxygens species such as superoxide anion radicals and hydroxyl radicals.
Rabdosiin could effectively overcome METTL8-mediated lenvatinib resistance.

物理化学性质&存储条件

分子量 718.62
分子式 C36H30O16
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(S)-2-(((1S,2R)-3-(((R)-1-Carboxy-2-(3,4-dihydroxyphenyl)ethoxy)carbonyl)-1-(3,4-dihydroxyphenyl)-6,7-dihydroxy-1,2-dihydronaphthalene-2-carbonyl)oxy)-3-(3,4-dihydroxyphenyl)propanoic acid

参考文献

1. Ito H, et al. Bioorg Med Chem. 1998 Jul;6(7):1051-6.

2. Liu Y, et al. Exp Cell Res. 2024 Dec 18;444(2):114389.

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