RY785 | Kv2 channel inhibitor | Probechem Biochemicals

Chemical Structure : RY785

CAS No.: 689297-68-5

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RY785 (RY-785)

货号: PC-38493Not For Human Use, Lab Use Only.

RY785 (RY-785) is a potent, selective voltage-gated potassium (Kv2) channels inhibitor with IC50 of 50 nM for Kv2.1 channel, possesses good selectivity over Kv1.2 (IC50>10 uM).

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5 mg	￥1180	In stock
10 mg	￥1880	In stock
25 mg	￥3280	In stock
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生物&药学活性

RY785 (RY-785) is a potent, selective voltage-gated potassium (Kv2) channels inhibitor with IC50 of 50 nM for Kv2.1 channel, possesses good selectivity over Kv1.2 (IC50>10 uM).
RY785 also displays no significant activity against CaV channel, and NaV channels.
RY785 (1 uM) block eliminates Kv2.1 current at all physiologically relevant voltages, inhibiting ≥98% of the Kv2.1 conductance in rat Kv2.1 (Kcnb1) channels heterologously expressed in CHO-K1 cells.
RY785 is an important chemical probe for the study of K(V)2 channels in biological systems.

物理化学性质&存储条件

分子量	392.477
分子式	C21H20N4O2S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3-(3-methoxyphenyl)-2-methyl-N-(2-(thiazol-4-yl)-1H-benzo[d]imidazol-5-yl)propanamide

参考文献

1. Herrington J, et al. Mol Pharmacol. 2011 Dec;80(6):959-64.

2. Marquis MJ, et al. J Gen Physiol. 2022 Jun 6;154(6):e202112981.

RY785 (RY-785)

生物&药学活性

物理化学性质&存储条件

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RY785 (RY-785)

生物&药学活性

物理化学性质&存储条件

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