RXR agonist 33

Chemical Structure : RXR agonist 33

加入收藏

货号: PC-21720Not For Human Use, Lab Use Only.

RXR agonist 33 is a highly potent, selective and partial RXR agonist with EC50 of 9/18/11 nM for RXRα/β/γ respectively.

规格	价格	库存	数量
50 mg		Get quote
100 mg		Get quote
200 mg		Get quote
1 g		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

RXR agonist 33 is a highly potent, selective and partial RXR agonist with EC50 of 9/18/11 nM for RXRα/β/γ respectively.
RXR agonist 33 shows favorable selectivity profile with no off-target effect at 1 μM on nuclear receptors related to RXR.
RXR agonist 33 robustly activates human RXR homodimer response element DR1 with EC50 of 0.16 uM.
RXR agonist 33 induces the expression of the RXR homodimer-regulated glycerophosphodiester phosphodiesterase 1 (GDE1) in HT29 cells.

物理化学性质&存储条件

分子量	361.83
分子式	C18H20ClN3O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3-((4-chloro-6-(4,4-dimethyl-3,4-dihydroquinolin-1(2H)-yl)pyrimidin-2-yl)oxy)propanoic acid

参考文献

1. Max Lewandowski, et al. J Med Chem. 2024 Jan 18. doi: 10.1021/acs.jmedchem.3c02095.

RXR agonist 33

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

RXR agonist 33

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Get Quotation Now

* Indicates a Required FieldYour information is safe with us.