RXFP3/4 agonist 4

Chemical Structure : RXFP3/4 agonist 4

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货号: PC-49433Not For Human Use, Lab Use Only.

RXFP3/4 agonist 4 is a potent, selective, nonpeptide dual RXFP3/4 agonist with EC50 of 82/2.0 nM in cellualr cAMP assays.

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生物&药学活性

RXFP3/4 agonist 4 is a potent, selective, nonpeptide dual RXFP3/4 agonist with EC50 of 82/2.0 nM in cellualr cAMP assays.
RXFP3/4 agonist 4 also exhibits GTPγS binding EC50 values 119 nM for RXFP3 and 11 nM for RXFP4.
RXFP3/4 agonist 4 also induces β-arrestin recruitment (EC50=4.9 uM relative to an EC50 of 83 nM for relaxin-3) in an RXFP3 overexpressing U2OS cell line.
RXFP3/4 agonist 4 engages both G protein-mediated cAMP signaling and G protein-independent β-arrestin recruitment, a profile shared by relaxin-3.

物理化学性质&存储条件

分子量	383.880
分子式	C20H22ClN5O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(E)-N-(4-chlorophenethyl)-2-((7-ethyl-5-hydroxy-1H-indol-3-yl)methylene)hydrazine-1-carboximidamide

参考文献

1. DeChristopher B, et al. Bioorg Med Chem Lett. 2019 Apr 15;29(8):991-994.

RXFP3/4 agonist 4

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物理化学性质&存储条件

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RXFP3/4 agonist 4

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