RXFP2 agonist 6641 | FXRP2 agonist | Probechem Biochemicals

Chemical Structure : RXFP2 agonist 6641

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RXFP2 agonist 6641 (Compound 6641)

货号: PC-49427Not For Human Use, Lab Use Only.

RXFP2 agonist 6641 is a highly potent, selective and full allosteric agonist of relaxin/insulin-like family peptide receptor 2 (RXFP2) with EC50 of 0.38 uM, Emax=107% (hFXRP2).

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生物&药学活性

RXFP2 agonist 6641 is a highly potent, selective and full allosteric agonist of relaxin/insulin-like family peptide receptor 2 (RXFP2) with EC50 of 0.38 uM, Emax=107% (hFXRP2).
Compound 6641 is also activate the mouse RXFP2 receptor, does not activate either human or mouse RXFP1 receptors and RXFP3 or RXFP4 receptors.
Compound 6641 is an allosteric agonist of RXFP2 that requires the RXFP2 transmembrane domain for activity.
Compound 6641 (3-5 uM) induces gubernacular invagination in mouse embryos， induces osteoblast mineralization in human osteoblasts in vitro, specifically activates the mouse RXFP2 receptor in vivo.
Compound 6641 treatment (10 mg/kg, PO) promotes bone formation in vivo.

物理化学性质&存储条件

分子量	787.377
分子式	C29H19F9IN3O5
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(S)-8-(3,5-bis(trifluoromethyl)phenyl)-2-(2-(2-iodo-4-(trifluoromethoxy)phenoxy)acetyl)-1,3,4,12a-tetrahydrobenzo[e]pyrazino[1,2-a][1,4]diazepine-6,12(2H,11H)-dione

参考文献

1. Esteban-Lopez M, et al. Commun Biol. 2022 Nov 4;5(1):1183.

RXFP2 agonist 6641 (Compound 6641)

生物&药学活性

物理化学性质&存储条件

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RXFP2 agonist 6641 (Compound 6641)

生物&药学活性

物理化学性质&存储条件

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