RX-375 | AMPK activator | Probechem Biochemicals

Chemical Structure : RX-375

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RX-375 (RX375, RX 375)

货号: PC-20473Not For Human Use, Lab Use Only.

RX-375 (RX375) is an indirect small-molecule activator of AMPK by directly binds to Prohibitins (PHB1 and PHB2), induces dissociation of AMPK-PHBs complex.

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生物&药学活性

RX-375 (RX375) is an indirect small-molecule activator of AMPK by directly binds to Prohibitins (PHB1 and PHB2), induces dissociation of AMPK-PHBs complex.
RX-375 does not activate recombinant AMPK proteins composed of α1β1γ1 or α2β1γ1 subunits in vitro at 100 uM.
RX-375 inhibits fatty acid synthesis in HepG2 cells in a PPARα-independent manner, 10,000 times more potent than metformin.
RX-375 exhibits stimulatory and inhibitory effects on AMPKα phosphorylation and fatty acid synthesis, respectively, in primary human hepatocytes.
RX-375 attenuates the interaction between AMPK and PHBs, PHBs are negative regulators of AMPK.
RX-375 (30 mg/kg, oral) increasees AMPKα phosphorylation level, reduces triglyceride content and inhibits fatty acid synthesis in the liver of obese mice.

物理化学性质&存储条件

分子量	407.45
分子式	C23H22FN3O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3-((1-ethylureido)methyl)-N-(4-(4-fluorophenoxy)phenyl)benzamide

参考文献

1. Kanagaki S, et al. iScience. 2023 Feb 28;26(4):106293.

RX-375 (RX375, RX 375)

生物&药学活性

物理化学性质&存储条件

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RX-375 (RX375, RX 375)

生物&药学活性

物理化学性质&存储条件

参考文献

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