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首页-小分子抑制剂&激动剂-Epigenetics-Bromodomain-RX-37
RX-37

Chemical Structure : RX-37

CAS No.: 1627715-60-9

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RX-37 (RX 37;RX37;BET bromodomain inhibitor RX-37)

货号: PC-60935Not For Human Use, Lab Use Only.

RX-37 (RX37) is a potent and specific BET bromodomain inhibitor with Ki of 3.2-24.7 nM for BD1 and BD2 domains of BRD2, BRD3, and BRD4.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    RX-37 (RX37) is a potent and specific BET bromodomain inhibitor with Ki of 3.2-24.7 nM for BD1 and BD2 domains of BRD2, BRD3, and BRD4.
    RX-37 shows an excellent selectivity over other non-BET bromodomain-containing proteins with the exception of CREBBP (Kd=670 nM).
    RX-37 potently and selectively inhibits cell growth in human acute leukemia cell lines harboring the rearranged MLL1 gene (IC50=20 nM for MV4;11 cells).

    物理化学性质&存储条件

    分子量 413.481
    分子式 C24H23N5O2
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20 °C 12 个月; 4°C 6 个月
    配置液
    -80 °C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    4-(1-(3-cyclopropyl-5-methyl-1H-pyrazol-4-yl)-8-methoxy-5H-pyrido[4,3-b]indol-7-yl)-3,5-dimethylisoxazole

    参考文献

    1. Ran X, et al. J Med Chem. 2015 Jun 25;58(12):4927-39.

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