RX-3117 |CAS:865838-26-2 Probechem Biochemicals

Chemical Structure : RX-3117

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RX-3117 (TV-1360;fluorocyclopentenylcytosine)

货号: PC-44249Not For Human Use, Lab Use Only.

RX-3117 (TV-1360, fluorocyclopentenylcytosine) is an orally available cytidine analog, nucleoside antimetabolite with potential antineoplastic activity.

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生物&药学活性

RX-3117 (TV-1360, fluorocyclopentenylcytosine) is an orally available cytidine analog, nucleoside antimetabolite with potential antineoplastic activity; Fluorocyclopentenylcytosine (RX-3117) is activated by uridine-cytidine kinase 2 (UCK2); shows potent efficacy in xenograft models, even in tumors that are resistant to gemcitabine.

Chemotherapeutic Agents

Phase 2 Clinical

物理化学性质&存储条件

分子量
分子式	C10H12FN3O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	DMSO: ≥ 50 mg/mL
Chemical Name/SMILES	2(1H)-Pyrimidinone, 4-amino-1-[(1S,4R,5S)-2-fluoro-4,5-dihydroxy-3-(hydroxymethyl)-2-cyclopenten-1-yl]-

参考文献

1. Peters GJ, et al. Invest New Drugs. 2013 Dec;31(6):1444-57.

2. Yang MY, et al. Anticancer Res. 2014 Dec;34(12):6951-9.

3. Sarkisjan D, et al. PLoS One. 2016 Sep 9;11(9):e0162901.

RX-3117 (TV-1360;fluorocyclopentenylcytosine)

生物&药学活性

物理化学性质&存储条件

参考文献

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RX-3117 (TV-1360;fluorocyclopentenylcytosine)

生物&药学活性

物理化学性质&存储条件

参考文献

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