RWJ-56110 |CAS:252889-88-6 Probechem Biochemicals

Chemical Structure : RWJ-56110

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RWJ-56110 (RWJ56110)

货号: PC-61304Not For Human Use, Lab Use Only.

RWJ-56110 is a potent, selective, peptide-mimetic PAR-1 antagonist with binding IC50 of 0.44 uM, with no effect on PAR-2, PAR-3, or PAR-4.

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生物&药学活性

RWJ-56110 is a potent, selective, peptide-mimetic PAR-1 antagonist with binding IC50 of 0.44 uM, with no effect on PAR-2, PAR-3, or PAR-4.
RWJ-56110 inhibits thrombin activates human platelets aggregation with IC50 of 0.34 uM.
RWJ-56110 also blocks angiogenesis association with endothelial cell growth suppression and induction of apoptosis.

物理化学性质&存储条件

分子量	863.65
分子式	C41H43Cl2F2N7O3.2HC
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(αS)-N-[(1S)-3-Amino-1-[[(phenylmethyl)amino]carbonyl]propyl]-α-[[[[1-[(2,6-dichlorophenyl)methyl]-3-(1-pyrrolidinylmethyl)-1H-indol-6-yl]amino]carbonyl]amino]-3,4-difluoro-benzenepropanamide

参考文献

1. Andrade-Gordon P, et al. Proc Natl Acad Sci U S A. 1999 Oct 26;96(22):12257-62.N9691

2. Zhang HC, et al. Bioorg Med Chem Lett. 2001 Aug 20;11(16):2105-9.

3. Tanaka M, et al. J Pharmacol Sci. 2016 Jul;131(3):162-71.

RWJ-56110 (RWJ56110)

生物&药学活性

物理化学性质&存储条件

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RWJ-56110 (RWJ56110)

生物&药学活性

物理化学性质&存储条件

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