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首页-小分子抑制剂&激动剂-Antibiotics and Antivirals-Bacterial-RWJ-49815
RWJ-49815

Chemical Structure : RWJ-49815

CAS No.: 193282-45-0

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RWJ-49815 (RWJ 49815, RWJ49815)

货号: PC-70181Not For Human Use, Lab Use Only.

RWJ-49815 is a potent bactericidal agent that inhibits the KinA autophosphorylation with IC50 of 1.6 uM.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    RWJ-49815 is a potent bactericidal agent that inhibits the KinA autophosphorylation with IC50 of 1.6 uM.
    RWJ-49815 inhibits the autophosphorylation of kinase A of the KinA-Spo0F two-component signal transduction system in vitro.
    RWJ-49815 suppresses growth of MRSA, vancomycin-resistant Enterococcus faecium, and penicillin-resistant Streptococcus pneumoniae (MICs=1-2 ug/ml).
    RWJ-49815 exhibits reduced resistance emergence in a laboratory passage experiment compared with quinolone and ciprofloxacin.

    物理化学性质&存储条件

    分子量 449.598
    分子式 C30H31N3O
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20 °C 12 个月; 4°C 6 个月
    配置液
    -80 °C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    1-(4-(3,3,3-triphenylpropoxy)phenethyl)guanidine

    参考文献

    1. Barrett JF, et al. Proc Natl Acad Sci U S A. 1998 Apr 28;95(9):5317-22.

    2. Stephenson K, et al. J Biol Chem. 2000 Dec 8;275(49):38900-4.

    3. Theodorou EC, et al. Cell Signal. 2011 Aug;23(8):1327-37.

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