RV1088 |CAS:1229606-73-8 Probechem Biochemicals

Chemical Structure : RV1088

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RV1088 (RV-1088, RV 1088)

货号: PC-63408Not For Human Use, Lab Use Only.

RV1088 is a potent narrow spectrum kinase inhibitor that target p38, c-Src, Syk or JAK individually, dose-dependently reduces TNF-α levels in LPS-activated macrophages with IC50 of 0.63 nM.

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生物&药学活性

RV1088 is a potent narrow spectrum kinase inhibitor that target p38, c-Src, Syk or JAK individually, dose-dependently reduces TNF-α levels in LPS-activated macrophages with IC50 of 0.63 nM.
RV1088 also reduces IL-6 production effectively with IC50 of 1.66 nM.
RV1088 is significantly more effective at inhibiting IL-6 and IL-8 production by monocytes and RA synovial fibroblasts compared with Humira; TNF-α, IL-6 and IL-8 synthesis in RA synovial membrane cells with low nM IC50s.

物理化学性质&存储条件

分子量	578.673
分子式	C33H34N6O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-[4-[[4-[[[[3-(1,1-dimethylethyl)-1-(4-methylphenyl)-1H-pyrazol-5-yl]amino]carbonyl]amino]-1-naphthalenyl]oxy]-2-pyridinyl]-2-methoxyacetamide

参考文献

1. To WS, et al. Br J Pharmacol. 2015 Aug;172(15):3805-16.

RV1088 (RV-1088, RV 1088)

生物&药学活性

物理化学性质&存储条件

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RV1088 (RV-1088, RV 1088)

生物&药学活性

物理化学性质&存储条件

参考文献

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