RV-1729 |CAS:1293915-42-0 Probechem Biochemicals

Chemical Structure : RV-1729

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RV-1729 (RV1729;RV 1729)

货号: PC-63407Not For Human Use, Lab Use Only.

RV-1729 is a potent, selective PI3Kδ inhibitor with IC50 of 12 nM, 2-fold selectivity for PI3Kδ relative to PI3Kγ and 16-fold over PI3Kα.

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1 g		Get quote

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生物&药学活性

RV-1729 is a potent, selective PI3Kδ inhibitor with IC50 of 12 nM, 2-fold selectivity for PI3Kδ relative to PI3Kγ and 16-fold over PI3Kα.
RV-1729 inhibits PMA-induced peroxide production in U937 cells and phosphorylation of Akt in MCP1-stimulated THP1 cells with IC50 of 1.1 and 46 nM.
RV-1729 significantly inhibits allergen-induced responses in murine models of asthma and COPD.

物理化学性质&存储条件

分子量	735.242
分子式	C39H39ClN8O5
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	6-(2-((4-amino-3-(3-hydroxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)methyl)-3-(2-chlorobenzyl)-4-oxo-3,4-dihydroquinazolin-5-yl)-N,N-bis(2-methoxyethyl)hex-5-ynamide

参考文献

1. Norman P. Expert Opin Ther Pat. 2014 Apr;24(4):471-5.

2. Respivert Ltd. Crystalline PI3 kinase inhibitors. WO2013136076; 2013

RV-1729 (RV1729;RV 1729)

生物&药学活性

物理化学性质&存储条件

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RV-1729 (RV1729;RV 1729)

生物&药学活性

物理化学性质&存储条件

参考文献

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