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首页-小分子抑制剂&激动剂-Wnt/Notch/Hedgehog-Hedgehog (Hh)-RUSKI-201
RUSKI-201

Chemical Structure : RUSKI-201

CAS No.: 1458031-48-5

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RUSKI-201 (RUSKI 201, RUSKI201)

货号: PC-70165Not For Human Use, Lab Use Only.

RUSKI-201 is a potent, selective and cell active Hedgehog acyltransferase (Hhat) inhibitor with IC50 of 0.87 uM.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    RUSKI-201 is a potent, selective and cell active Hedgehog acyltransferase (Hhat) inhibitor with IC50 of 0.87 uM.
    RUSKI-201 blocks Hh signaling in H520, Panc-1, and MCF-7 coculture with Shh-Light2 cells (IC50=4.8 uM, 7.8 uM, and 8.5 uM, respectively).
    RUSKI-201 selectively inhibits Hh palmitoylation over a panel of >100 palmitoylated substrates in cells.

    物理化学性质&存储条件

    分子量 357.516
    分子式 C20H27N3OS
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20 °C 12 个月; 4°C 6 个月
    配置液
    -80 °C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    1-[6,7-Dihydro-4-(6-methyl-2-pyridinyl)thieno[3,2-c]pyridin-5(4H)-yl]-2-[(2-methylbutyl)amino]ethanone

    参考文献

    1. Rodgers UR, et al. ACS Chem Biol. 2016 Dec 16;11(12):3256-3262.

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