RUNX1/ETO inhibitor 7.44

Chemical Structure : RUNX1/ETO inhibitor 7.44

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货号: PC-49279Not For Human Use, Lab Use Only.

规格	价格	库存	数量
25 mg		Get quote
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

RUNX1-ETO inhibitor 7.44 is a first-in-class, small-molecule inhibitor of RUNX1/ETO tetramerization, specifically interferes the nervy homology region 2 (NHR2) domain of ETO mediating tetramerization with Klig value of 3.75 uM.
RUNX1-ETO inhibitor 7.44 targets the interaction between the NHR2 domain of RUNX1/ETO, interferes with NHR2 tetramer stability and leads to an increase in the dimer population of NHR2.
RUNX1-ETO inhibitor 7.44 binds with both heteroaromatic moieties to NHR2 and interacts with or leads to conformational changes in the N-termini of the NHR2 tetramer.
RUNX1-ETO inhibitor 7.44 has favorable physicochemical, pharmacokinetic, and toxicological properties, shows anti-leukemic effects.

物理化学性质&存储条件

分子量	342.303
分子式	C18H14O7
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2,4-bis(benzo[d][1,3]dioxol-5-yl)-4-oxobutanoic acid

参考文献

1. Mohanraj Gopalswamy, et al. Sci Rep. 2022 Aug 19;12(1):14158.