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首页-小分子抑制剂&激动剂-Nuclear Receptor/Transcription Factor-RUNX1-CBFβ-RUNX1-IN-17
RUNX1-IN-17

Chemical Structure : RUNX1-IN-17

CAS No.: 493028-20-9

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RUNX1-IN-17

货号: PC-61298Not For Human Use, Lab Use Only.

RUNX1-IN-17 is a potent, allosteric inhibitor of CBFβ-RUNX1 interaction with IC50 of 3.2 uM in FRET assays.

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10 mg ￥1280 In stock
25 mg ￥1980 In stock
50 mg ￥2980 In stock
100 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

RUNX1-IN-17 is a potent, allosteric inhibitor of CBFβ-RUNX1 interaction with IC50 of 3.2 uM in FRET assays.
RUNX1-IN-17 binds to CBFβ at a site displaced from the binding interface for Runx1.
RUNX1-IN-17 decreases proliferation in human leukemia cell line ME-1.

物理化学性质&存储条件

分子量 234.317
分子式 C12H14N2OS
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

5-ethyl-4-(4-methoxyphenyl)thiazol-2-amine

参考文献

1. Gorczynski MJ, et al. Chem Biol. 2007 Oct;14(10):1186-97.

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