RUN-47 | NRF1 activator | Probechem Biochemicals

Chemical Structure : RUN-47

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RUN-47 (RUN47)

货号: PC-24039Not For Human Use, Lab Use Only.

RUN-47 is a small-molecule activator of NRF1 with EC50 of 6.43 uM in 3xPSMA4-ARE-LUC reporter assays, specifically activates NRF1 pathway.

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生物&药学活性

RUN-47 is a small-molecule activator of NRF1 with EC50 of 6.43 uM in 3xPSMA4-ARE-LUC reporter assays, specifically activates NRF1 pathway.
RUN-47 does not activates ROS, inhibits the UPS, or affects the cell cycle.
RUN-47 modulates proteasome activity, autophagy, and increase cell survival under proteotoxic and oxidative stress.
RUN-47 acts upstream of NRF1, stabilizing NRF1, and this stabilization effectively leads to NRF1 transcriptional activation.
RUN-47 prevents protein aggregate formation in cells, reduces the formation of Lewy body-like aggregates in SH-SY5Y cells overexpressing SNCA-EGFP.
RUN-47 activates SKN-1 A/NRF1 in C. elegans, prevents aggregate formation, and reduces sensitivity to juglone-induced oxidative stress in vivo.
RUN-47 also reduces the formation of α-synuclein aggregates in C. elegans, demonstrates a significant protective effect against juglone-induced lethal oxidative stress.

物理化学性质&存储条件

分子量	451.52
分子式	C26H29NO6
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(3,5-bis((E)-3,4-dimethoxybenzylidene)-4-oxocyclohexyl)acetamide

参考文献

1. Sedlacek J, et al. Biomed Pharmacother. 2025 Jan 28;183:117864.

RUN-47 (RUN47)

生物&药学活性

物理化学性质&存储条件

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RUN-47 (RUN47)

生物&药学活性

物理化学性质&存储条件

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