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首页-小分子抑制剂&激动剂-Others-Other Targets-RU.521
RU.521

Chemical Structure : RU.521

CAS No.: 2262452-06-0

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RU.521 (RU521, RU-320521 )

货号: PC-60018Not For Human Use, Lab Use Only.

RU.521 (RU521, RU-320521) is a potent, selective cyclic GMP-AMP synthase (cGAS) inhibitor with Kd of 36.2 nM.

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纯度 & COA & 质检文件 纯度: >95% (HPLC) Select Batch:

生物&药学活性

RU.521 (RU521, RU-320521) is a potent, selective cyclic GMP-AMP synthase (cGAS) inhibitor with Kd of 36.2 nM.
RU.521 inhibits cGAS-mediated interferon upregulation in cellular assays, with no effect on inflammatory pathways independent of cGAS.
RU.521 suppresses the chronically elevated levels of type I interferon in primary macrophages from mice model of AGS (Aicardi-Goutières syndrome).

物理化学性质&存储条件

分子量 415.23
分子式 C19H12Cl2N4O3
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

3-[1-(6,7-dichloro-1H-benzimidazol-2-yl)-5-hydroxy-3-methyl-pyrazol-4-yl]-3H-isobenzofuran-1-one

参考文献

1. Vincent J, et al. Nat Commun. 2017 Sep 29;8(1):750.

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