RU-SKI 43 hydrochloride |CAS:1782573-67-4 Probechem Biochemicals

Chemical Structure : RU-SKI 43 hydrochloride

CAS No.: 1782573-67-4

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RU-SKI 43 hydrochloride (RU-SKI43 hydrochloride)

货号: PC-45464Not For Human Use, Lab Use Only.

RU-SKI 43 hydrochloride is a small molecule inhibitor of Hhat (Hedgehog acyltransferase) with IC50 of 0.85 uM.

规格	价格	库存
5 mg	￥1180	In stock
10 mg	￥1780	In stock
25 mg	￥2980	In stock
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

RU-SKI 43 hydrochloride is a small molecule inhibitor of Hhat (Hedgehog acyltransferase) with IC50 of 0.85 uM.
RU-SKI 43 hydrochloride is specific to Shh palmitoylation and no effect for palmitoylation of H-Ras, Fyn and myristoylation of c-Src.
RU-SKI 43 hydrochloride reduces pancreatic cancer cell proliferation and Gli-1 activation through Smoothened-independent non-canonical signaling, inhibits two key proliferative pathways regulated by Akt and mTOR.

物理化学性质&存储条件

分子量	423.0117
分子式	C22H31ClN2O2S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	DMSO: ≥ 51 mg/mL
Chemical Name/SMILES	Ethanone, 1-[6,7-dihydro-4-[(3-methylphenoxy)methyl]thieno[3,2-c]pyridin-5(4H)-yl]-2-[(2-methylbutyl)amino]-, hydrochloride

参考文献

1. Petrova E, et al. Nat Chem Biol. 2013 Apr;9(4):247-9.

2. Petrova E, et al. Oncogene. 2015 Jan 8;34(2):263-8.

3. Matevossian A, et al. Mol Cancer. 2015 Apr 1;14:72.

RU-SKI 43 hydrochloride (RU-SKI43 hydrochloride)

生物&药学活性

物理化学性质&存储条件

参考文献

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RU-SKI 43 hydrochloride (RU-SKI43 hydrochloride)

生物&药学活性

物理化学性质&存储条件

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