RU-A1 | BMI-1 inhibitor | Probechem Biochemicals

Chemical Structure : RU-A1

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RU-A1 (BMI-1 inhibitor RU-A1)

货号: PC-61790Not For Human Use, Lab Use Only.

RU-A1 is a novel potent BMI1 inhibitor that targets cellular self-renewal in hepatocellular carcinoma (HCC).

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生物&药学活性

RU-A1 is a novel potent BMI1 inhibitor that targets cellular self-renewal in hepatocellular carcinoma (HCC).
RU-A1 downregulates BMI1 expression, impaires cell viability, reduces cell migration, and sensitizes HCC cells to 5-FU in vitro.
RU-A1 effectively reduces cancer stem-like cells (CSCs) content, and abrogates tumor growth in vivo in zebrafish.

物理化学性质&存储条件

分子量	337.401
分子式	C17H15N5OS
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(4-methoxyphenyl)-4-(2-methylimidazo[1,2-a]pyrimidin-3-yl)thiazol-2-amine

参考文献

1. Bartucci M, et al. Target Oncol. 2017 Aug;12(4):449-462.

RU-A1 (BMI-1 inhibitor RU-A1)

生物&药学活性

物理化学性质&存储条件

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RU-A1 (BMI-1 inhibitor RU-A1)

生物&药学活性

物理化学性质&存储条件

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