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首页-小分子抑制剂&激动剂-Tyrosine Kinase-TAM Receptor (Tyro3-Axl-Mer)-RU-301
RU-301

Chemical Structure : RU-301

CAS No.: 1110873-99-8

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RU-301 (RU 301, RU301)

货号: PC-60246Not For Human Use, Lab Use Only.

RU-301 (RU301) is a small molecule pan-TAM (Tyro3-Axl-Mer)) inhibitor that targets the TAM Ig1-Gas6 interface, blocks Gas6-dependent TAM activation.

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5 mg ￥1980 In stock
10 mg ￥2980 In stock
25 mg ￥4880 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

RU-301 (RU301) is a small molecule pan-TAM (Tyro3-Axl-Mer)) inhibitor that targets the TAM Ig1-Gas6 interface, blocks Gas6-dependent TAM activation.
RU-301 effectively blocks Gas6-inducible Axl receptor activation with low micromolar IC50s.
RU-301 inhibits Gas6-inducible motility in Axl-expressing cell lines.
RU-301 suppress H1299 lung cancer tumor growth in a mouse xenograft NOD-SCIDγ model.

物理化学性质&存储条件

分子量 480.462
分子式 C21H19F3N4O4S
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

2-(((3-methylisoxazol-5-yl)methyl)thio)-N-(2-((2-nitro-4-(trifluoromethyl)phenyl)amino)ethyl)benzamide

参考文献

1. Kimani SG, et al. Sci Rep. 2017 Mar 8;7:43908.

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